Which syndrome is known to cause delayed dental eruption?

Down syndrome, also known as Trisomy 21, is associated with delayed dental eruption due to several factors. Individuals with Down syndrome often exhibit developmental delays, which can extend to various physiological processes, including the timing of tooth eruption. This syndrome also features characteristic dental anomalies such as abnormal spacing, smaller teeth, and an overall difference in the dental arch form, which can contribute to a change in the expected timeline for when teeth emerge.

In addition to developmental delays, the presence of hypotonia (decreased muscle tone) in individuals with Down syndrome may also influence the eruption process, as the muscle tone plays a role in the positioning of the jaw and other structures that affect tooth eruption. Thus, it is well-recognized that those with Down syndrome may experience a significant delay in both primary and permanent tooth eruption compared to their peers. These factors collectively make Down syndrome the syndrome most prominently associated with delayed dental eruption among the listed options.